RGB or CMYK?

I am curious about what palette to use for what purpose. I know you are supposed to use CMYK palette when designing for separations printing processes, but on the other hand - you could use the RGB palette just as well, if you have a color calibrated system and a printer profile and if you leave a PDF to the printer, which I suppose most people do. It works if you set the color output to CMYK and use the printer ICC profile for conversion.

So, what is your choice regarding color models? It would be interesting to hear how you all work.

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