What's the best way to create a PDF in DRAW

Hi Everybody,
For starters, I'm trying to come to grips with PDF creation in DRAW X6.  I'll move on to PagePlus after my mind clears on the basics.
I will want to print a newsletter containing text, vector image, and a photo imported into DRAW.
So here are my first few questions.
1.  What PDF standard should I use for offset printing and what format for a professional ink jet printer.
2.  Should I make the PDF file from:
--- SAVE AS > PDF
--- Print > Adobe PDF
--- Corel PDF Creator
2.  Does it matter if the file is sRGB or SWOP-2 color mode.
3.  Do all images have to be converted to the same color space.
4.   Can I create a different color space for each page.
4.  Should I make separation files for either offset or inkjet printing.
Thanks for any suggestions.
Phil