Printing PDF High Res Layout

I will appreciate very much if someone can help me on how to print PDF layouts w/ full details such as transparencies or gradients. The problem I'm having is that my computer crash or simply taking too long to process. In order to achieve and print as PDF, I have to convert the layout to lowest bitmap resolution which degrades the look of the layout.I'm asking if there is a settings to consider and obtain good quality PDF, so I'm able to share with my clients w/o losing quality when they look at it.

Thanks